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Read moreDualsteric (or bitopic) ligands represent a novel mode of targeting G protein-coupled receptors (GPCRs). These compounds attach simultaneously to the orthosteric binding site and an additional allosteric binding area of...
Read moreNeuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. They are broadly distributed across the peripheral nervous system (PNS)...
Read moreDesign and synthesis of cold precursors of radiotracers for positron emission tomography (PET) as putative diagnostic probes in preclinical phase for reaching the target, defining the stage of the disease,...
Read more“The Light Side of the Drugs” Light is an unparalleled external signal to noninvasively manipulate biological systems with high spatial and temporal resolution. Photopharmacology relies on the use of molecular...
Read morePolypharmacology refers to the development and the use of pharmaceutical agents that act on multiple targets or disease pathways. It is generally thought that complex diseases – such as central nervous...
Read moreTargeted protein degradation based on proteolysis-targeting chimeras (PROTACs) is a rapidly developing technology for the inhibition of protein function, via direct degradation mediated by ubiquitin-proteasome system. PROTACs are hetero-bifunctional small...
Read moreCombining expertise and resources to answer bigger and more complex scientific questions and expand the breadth of our research
Read more2023 2022 2021 2020 For the complete list of publications for each member please click below: Marco De Amici Clelia Dallanoce Carlo Matera Claudio Papotto
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