Dualsteric (or bitopic) ligands represent a novel mode of targeting G protein-coupled receptors (GPCRs). These compounds attach simultaneously to the orthosteric binding site and an additional allosteric binding area of...
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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. They are broadly distributed across the peripheral nervous system (PNS)...
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Design and synthesis of cold precursors of radiotracers for positron emission tomography (PET) as putative diagnostic probes in preclinical phase for reaching the target, defining the stage of the disease,...
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“The Light Side of the Drugs” Light is an unparalleled external signal to noninvasively manipulate biological systems with high spatial and temporal resolution. Photopharmacology relies on the use of molecular...
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Polypharmacology refers to the development and the use of pharmaceutical agents that act on multiple targets or disease pathways. It is generally thought that complex diseases – such as central nervous...
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Targeted protein degradation based on proteolysis-targeting chimeras (PROTACs) is a rapidly developing technology for the inhibition of protein function, via direct degradation mediated by ubiquitin-proteasome system. PROTACs are hetero-bifunctional small...
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