dualsteric ligand

Dualsteric Ligands

Dualsteric (or bitopic) ligands represent a novel mode of targeting G protein-coupled receptors (GPCRs). These compounds attach simultaneously to the orthosteric binding site and an additional allosteric binding area of...

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nicotinic receptor

Nicotinic Acetylcholine Receptor Ligands

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. They are broadly distributed across the peripheral nervous system (PNS)...

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PET imaging

PET Radiotracers

Design and synthesis of cold precursors of radiotracers for positron emission tomography (PET) as putative diagnostic probes in preclinical phase for reaching the target, defining the stage of the disease,...

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photoswitchable ligand


“The Light Side of the Drugs” Light is an unparalleled external signal to noninvasively manipulate biological systems with high spatial and temporal resolution. Photopharmacology relies on the use of molecular...

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conceptual design of hybrid ligands


Polypharmacology refers to the development and the use of pharmaceutical agents that act on multiple targets or disease pathways. It is generally thought that complex diseases – such as central nervous...

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scheme of the project

Targeted Protein Degraders

Targeted protein degradation based on proteolysis-targeting chimeras (PROTACs) is a rapidly developing technology for the inhibition of protein function, via direct degradation mediated by ubiquitin-proteasome system. PROTACs are hetero-bifunctional small...

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