Marco De Amici received his master’s degree in Chemistry from the University of Pavia in 1979. He became assistant professor of Medicinal Chemistry at the University of Milan in 1983 and, following a research period at the Royal Danish School of Pharmacy in Copenhagen (NATO fellowship), he was appointed as associate professor of Medicinal Chemistry at the University of Trieste in 1992. Since 2000 he is full professor of Medicinal Chemistry at the Department of Pharmaceutical Sciences of the University of Milan, where he currently teaches “Medicinal Chemistry 2” and “Advanced Methodologies in Medicinal Chemistry”. Since 2014 he is a member of the Quality Assurance Board, designated by the Rector, which is responsible for implementing the quality policies of the University of Milan.
His scientific interests mainly fucus on the design and synthesis of small molecules targeting acetylcholine muscarinic or nicotinic receptors, in particular dual-acting compounds and dualsteric (i.e., orthosteric/allosteric) ligands. De Amici’s work on dualsteric ligands led to major contributions to the understanding of the mechanisms of activation and signaling of G protein-coupled receptors.
Marco De Amici has published to date over 140 peer-reviewed research papers in qualified international medicinal chemistry and multidisciplinary journals, such as the Journal of Medicinal Chemistry, Nature Communications and Nature Chemical Biology, among others, and has an h-index of 28 (Scopus, May 2022). Moreover, he is co-inventor of 4 patents. Over his career he has supervised several PhD students.
Research interests: polypharmacology | dualsteric ligands | GPCRs | muscarinic receptors | nicotinic receptors | 1,3-dipolar cycloaddition