Projects

Design and synthesis of cold precursors of radiotracers for positron emission tomography (PET) as putative diagnostic probes in preclinical phase for reaching the target, defining the stage of the disease,...

“The Light Side of the Drugs” (semi-quote :)) Light is an unparalleled external signal to noninvasively manipulate biological systems with high spatial and temporal resolution. Photopharmacology relies on the use...

Targeted protein degradation based on proteolysis-targeting chimeras (PROTACs) is a rapidly advancing strategy for modulating protein function through their selective removal via the ubiquitin–proteasome system. PROTACs are hetero-bifunctional small molecules...

Stable isotopes, such as 13C, 2H, 18O, and 15N, are powerful tools in pharmacological research, advancing our understanding of biochemical processes and optimizing drug development. One of their key uses is in metabolic pathway studies,...

Polypharmacology refers to the development and the use of pharmaceutical agents that act on multiple targets or disease pathways. It is generally thought that complex diseases – such as central nervous...

Dualsteric (or bitopic) ligands represent a novel mode of targeting G protein-coupled receptors (GPCRs). These compounds attach simultaneously to the orthosteric binding site and an additional allosteric binding area of...

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate fast neurotransmission in the central and peripheral nervous systems. They are broadly distributed across the peripheral nervous system (PNS)...